This literary analysis examines Flannery O`Connor`s Wise Blood (1952) as an indirect critique of man`s relation to eternity through the natural (material) depicted in the protagonist Hazel Motes and his doppelganger Enoch Emory. The interpretative essay focuses on the development of these two characters and the significance behind their ¿wise blood¿, keeping in perspective important philosophical as well as theological frameworks that provide essential concepts to interpret both character`s final transformation. As a major conclusion, man`s blood mirrors the interior man: Enoch`s inner being reflects the animal, while Hazel`s reflects enlightenment.